Instruments of the Earth Radiation Budget Experiment (ERBE) are operating on three different Earth orbiting spacecrafts: the Earth Radiation Budget Satellite (ERBS), NOAA-9, and NOAA-10. An overview is presented of the ERBE mission, in-orbit environments, and instrument design and operational features. An overview of science data processing and validation procedures is also presented. In-flight operations are described for the ERBE instruments aboard the ERBS and NOAA-9. Calibration and other operational procedures are described, and operational and instrument housekeeping data are presented and discussed.